KEGG   Saccharomyces cerevisiae (budding yeast): YDL042C
Entry
YDL042C           CDS       T00005                                 
Symbol
SIR2, MAR1
Name
(RefSeq) NAD-dependent histone deacetylase SIR2
  KO
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
Organism
sce  Saccharomyces cerevisiae (budding yeast)
Pathway
sce00760  Nicotinate and nicotinamide metabolism
sce01100  Metabolic pathways
sce04213  Longevity regulating pathway - multiple species
Brite
KEGG Orthology (KO) [BR:sce00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    YDL042C (SIR2)
 09150 Organismal Systems
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    YDL042C (SIR2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:sce03032]
    YDL042C (SIR2)
   03036 Chromosome and associated proteins [BR:sce03036]
    YDL042C (SIR2)
Enzymes [BR:sce01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     YDL042C (SIR2)
DNA replication proteins [BR:sce03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Telomere proteins
    SIR proteins
     YDL042C (SIR2)
Chromosome and associated proteins [BR:sce03036]
 Eukaryotic type
  Histone modification proteins
   Sir proteins
    YDL042C (SIR2)
SSDB
Motif
Pfam: SIR2 DUF592 TPP_enzyme_M
Other DBs
NCBI-GeneID: 851520
NCBI-ProteinID: NP_010242
SGD: S000002200
UniProt: P06700
Structure
Position
IV:complement(376757..378445)
AA seq 562 aa
MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL
NT seq 1689 nt   +upstreamnt  +downstreamnt
atgaccatcccacatatgaaatacgccgtatcaaagactagcgaaaataaggtttcaaat
acagtaagccccacacaagataaagacgcgatcagaaaacaacccgatgacattataaat
aatgatgaaccttcacataagaagataaaagtagcacagccggattccttgagggaaacc
aacacaacagatccacttgggcacactaaagctgcgctcggagaagtggcatcgatggag
ctcaaaccaactaatgacatggatcccttggcagtgtcagcagcttcagtagtgtcaatg
tccaatgacgttttgaaaccagagacgcccaaggggccaatcataatcagtaaaaaccca
tcaaatggtattttctatggtccctccttcactaaacgagagtctctcaatgctcgaatg
tttctgaaatactatggtgcacacaaatttttagacacttacctccccgaggatttgaac
tcgttatacatttactatcttatcaagttgctaggctttgaagttaaagatcaagcgctt
atcggcaccatcaacagtattgtccatatcaactcgcaagagcgtgttcaagatttggga
agtgcaatatctgtcacaaatgttgaagacccattggcaaaaaagcaaacagttcgtcta
atcaaagatttgcaaagagcaattaacaaagttctatgtacaagattaagattatccaat
tttttcactattgatcattttattcaaaaattacataccgctagaaaaattttggtcctg
actggtgcaggtgtttcaacttcattagggatcccggacttcagatcttctgaggggttc
tattcaaagatcaaacatttggggctcgatgatccccaagacgttttcaattacaatata
tttatgcacgacccctctgttttctataatattgccaatatggttttacctccagaaaaa
atttattctccattgcatagtttcattaagatgctacaaatgaaagggaaattattgaga
aattatactcaaaacattgataatttggaatcttatgcgggaataagcacagataaactg
gtgcagtgccatggctcttttgctactgccacctgcgttacctgccattggaacctaccc
ggtgagaggatatttaataaaattagaaacctcgaacttccactatgcccgtactgttac
aaaaaaagaagagaatatttcccagagggatataataataaagtaggtgttgctgcatca
cagggttcaatgtcggaaaggcctccatatatccttaactcatatggcgttctcaaacca
gatatcacattctttggcgaagcactgccaaataaatttcataagagcattcgcgaagat
atcttagaatgtgatttgttgatttgcattgggacaagtttaaaagtagcgccagtgtct
gaaatcgtaaacatggttccttcccacgttccccaagtcctgattaatcgtgatcccgtc
aagcacgcagaatttgatttatctcttttggggtactgtgatgacattgcagctatggta
gcccaaaaatgtggctggacgattccgcataagaaatggaacgatttgaagaacaagaac
tttaaatgccaagagaaggataagggcgtgtatgtcgttacatcagatgaacatcccaaa
accctctaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (51)   

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